Alternative names:

MTC;p140-TrkA;TRK;Trk-A;TRK1;TRKA

Description:

Recombinant Human NTRK1 Protein with C-terminal human Fc tag

Background:

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Molecular characterization:

NTRK1(Ala33-Phe410) hFc(Glu99-Ala330)

Molecular weight:

The protein has a predicted molecular mass of 67.4 kDa after removal of the signal peptide.The apparent molecular mass of NTRK1-hFc is approximately 70-130 kDa due to glycosylation.

Tag:

C-Human Fc Tag

Expression host:

HEK293

Target:

NTRK1

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com