Alternative names:

ANGPT2;GPT2;NG2;ngiopoietin-2

Description:

Recombinant human ANGPT2 protein with C-terminal human Fc tag

Background:

The protein encoded by this gene is an antagonist of angiopoietin 1 (Ang-1), and both (Ang-1 and Ang-2) are ligands for the endothelial tyrosine kinase receptor (Tie2). These two ligands affect angiogenesis during embryogenesis and tumorigenesis. The encoded protein disrupts the vascular remodeling ability of Ang-1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.

Molecular characterization:

ANGPT2(Lys275-Phe496) hFc(Glu99-Ala330)

Molecular weight:

The protein has a predicted molecular mass of 49.94 kDa after removal of the signal peptide.

Tag:

C-Human Fc Tag

Expression host:

HEK293

Target:

ANGPT2

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com