Alternative Name(s):

(Glucose transporter type 9)(GLUT-9)(Urate transporter)

Species: (Organism)

Homo sapiens (Human)

Gene Names:

SLC2A9

Tag info:

N-terminal 10xHis-tagged

Target Protein AA Sequence:

MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP

Expression Region:

1-540aa

Subcellular Location:

Tissue Specificity:

Protein Length:

Full Length

Pathway:

Mol. Weight:

60.2 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Metabolism

Function:

Involvement in disease:

Relevance:

High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules . May have a residual high-affinity, low-capacity glucose and fructose transporter activity . Transports urate at rates 45- to 60-fold faster than glucose . Does not transport galactose . May mediate small uptake of adenine but not of other nucleobases .

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

"SLC2A9 is a high-capacity urate transporter in humans." Caulfield M.J., Munroe P.B., O'Neill D., Witkowska K., Charchar F.J., Doblado M., Evans S., Eyheramendy S., Onipinla A., Howard P., Shaw-Hawkins S., Dobson R.J., Wallace C., Newhouse S.J., Brown M., Connell J.M., Dominiczak A., Farrall M. Cheeseman C. PLoS Med. 5:e197-e197(2008)