Alternative Name(s):

(C1 esterase)(Complement component 1 subcomponent s-B)

Species: (Organism)

Mus musculus (Mouse)

Gene Names:

C1sb

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

EPTMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEEGRLCGQRTSKSPNSPIIEEFQFPYNKLQVVFTSDFSIEEQFTGFAAYYTAIDVNECTDFTDVPCSHFCNNFIGGYFCSCPPEYFLHDDMRNCGVNCSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMQREDFDVEPADSEGNCPDSLTFAAKNQQFGPYCGDGFPGPLTIRTQSNTLGIVFQTDLMGQKKGWKLRYHGDPISCPKESTANSNWEPDKAKYVFKDVVKITCVDGFEVVEGHVSSTSYYSTCQSDGQWSNSGLKCQPVYCGIPDPIANGKVEEPENSVFGTVIHYTCEEPYYYMEHEEGGEYRCAANGRWVNDQLGIELPRCIPVCGVPTEPFQVQQKIFGGQPAKIENFPWQVFFNHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADLENAQRLYTKRVIIHPGWKEDDDLNPRTNFDNDIALVQLKDPVKMGPKFSPICLPGTSSEYNLSPGDMGLISGWGRTEKRLHVINLRGAKVPVTSLETCKQVKEENPTARPEDYVITDNMICAGEKGVDSCKGDSGGAFAFQVPNVKAPKFYVAGLVSWGKKCGAYGVYTKVKNYVDWILKTMQENSGPRKD

Expression Region:

16-688aa

Subcellular Location:

Tissue Specificity:

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

80.9 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Involvement in disease:

Relevance:

C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

"Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system." Garnier G., Circolo A., Xu Y., Volanakis J.E. Biochem. J. 371:631-640(2003)