Alternative Name(s):

(GFAP)

Species: (Organism)

Homo sapiens (Human)

Gene Names:

GFAP

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

LTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM

Expression Region:

292-432aa

Subcellular Location:

Tissue Specificity:

Protein Length:

Partial

Pathway:

Mol. Weight:

20.6 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Neuroscience

Function:

Involvement in disease:

Relevance:

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

"GFAP mutations, age at onset, and clinical subtypes in Alexander disease." Prust M., Wang J., Morizono H., Messing A., Brenner M., Gordon E., Hartka T., Sokohl A., Schiffmann R., Gordish-Dressman H., Albin R., Amartino H., Brockman K., Dinopoulos A., Dotti M.T., Fain D., Fernandez R., Ferreira J. Vanderver A. Neurology 77:1287-1294(2011)