Alternative Name(s):

Islet cell antigen 512 Short name: ICA 512 Islet cell autoantigen 3 PTP IA-2

Species: (Organism)

Homo sapiens (Human)

Gene Names:

PTPRN

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

VSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMR

Expression Region:

35-575aa

Subcellular Location:

Membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, secretory vesicle membrane, Single-pass type I membrane protein, Perikaryon, Cell projection, axon, Cell junction, synapse, Cell membrane, Single-pass type I membrane protein, Endosome

Tissue Specificity:

Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.

Protein Length:

Extracellular Domain

Pathway:

Mol. Weight:

59.3 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Signal Transduction

Function:

Plays a role in vesicle-mediated secretory processes

Involvement in disease:

Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Relevance:

Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Protein-tyrosine phosphatase family, Receptor class 8 subfamily

Reference:

"Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma."Lan M.S., Lu J., Goto Y., Notkins A.L.DNA Cell Biol. 13:505-514(1994)