Alternative Name(s):

Paragonial peptide B Sex peptide Short name: SP

Species: (Organism)

Drosophila melanogaster (Fruit fly)

Gene Names:

SP

Tag info:

Tag-Free

Target Protein AA Sequence:

WEWPWNRKPTKFPIPSPNPRDKWCRLNLGPAWGGRC

Expression Region:

20-55aa

Subcellular Location:

Secreted

Tissue Specificity:

Main cells of the accessory glands of males (paragonial gland).

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

4.3 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila

Involvement in disease:

Relevance:

Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:3135120, PubMed:19249273, PubMed:20308537, PubMed:19793753, PubMed:15694303, PubMed:24089336). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20458515, PubMed:20308537, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:3135120, PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336).

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Drosophila sex peptide family

Reference:

"Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon."Panhuis T.M., Swanson W.J., Nunney L.Evolution 57:2785-2791(2003)