Alternative Name(s):

Anticoagulant protein C Autoprothrombin IIA Blood coagulation factor XIV

Species: (Organism)

Rattus norvegicus (Rat)

Gene Names:

Proc

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

ANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCRCAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL

Expression Region:

42-461aa

Subcellular Location:

Secreted, Golgi apparatus, Endoplasmic reticulum

Tissue Specificity:

Plasma; synthesized in the liver.

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

49.3 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Cardiovascular

Function:

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Involvement in disease:

Relevance:

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Peptidase S1 family

Reference:

"Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis." Heuer J.G., Sharma G.R., Gerlitz B., Zhang T., Bailey D.L., Ding C., Berg D.T., Perkins D., Stephens E.J., Holmes K.C., Grubbs R.L., Fynboe K.A., Chen Y.F., Grinnell B., Jakubowski J.A. Crit. Care Med. 32:1570-1578(2004)