Alternative Name(s):

Class E basic helix-loop-helix protein 37 ;bHLHe37

Species: (Organism)

Homo sapiens (Human)

Gene Names:

MYCN

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC

Expression Region:

1-464aa

Subcellular Location:

Nucleus

Tissue Specificity:

Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).

Protein Length:

Full Length

Pathway:

Mol. Weight:

51.6 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Cancer

Function:

Positively regulates the transcription of MYCNOS in neuroblastoma cells.

Involvement in disease:

Feingold syndrome 1 (FGLDS1)

Relevance:

May function as a transcription factor.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

Nucleotide sequence of the human N-myc gene.Stanton L.W., Schwab M., Bishop J.M.Proc. Natl. Acad. Sci. U.S.A. 83:1772-1776(1986)