Alternative Name(s):

Angiotensin II type-2 receptor ;AT2

Species: (Organism)

Rattus norvegicus (Rat)

Gene Names:

Agtr2

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLE

Expression Region:

1-45aa

Subcellular Location:

Cell membrane, Multi-pass membrane protein

Tissue Specificity:

Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.

Protein Length:

Extracellular Domain

Pathway:

Mol. Weight:

6.9 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity).

Involvement in disease:

Relevance:

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation .

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

G-protein coupled receptor 1 family

Reference:

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., Inagami T.J. Biol. Chem. 268:24543-24546(1993)