Alternative Name(s):

MCP-1-related chemokine;Monocyte chemoattractant protein 5Monocyte chemotactic protein 5 ;MCP-5Small-inducible cytokine A12

Species: (Organism)

Mus musculus (Mouse)

Gene Names:

Ccl12

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

GPDAVSTPVTCCYNVVKQKIHVRKLKSYRRITSSQCPREAVIFRTILDKEICADPKEKWVKNSINHLDKTSQTFILEPSCLG

Expression Region:

23-104aa

Subcellular Location:

Secreted

Tissue Specificity:

Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

13.3 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

Involvement in disease:

Relevance:

Chotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Intercrine beta (chemokine CC) family

Reference:

Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation.Jia G.-Q., Gonzalo J.A., Lloyd C., Kremer L., Lu L., Martinez A.C., Wershil B.K., Gutierrez-Ramos J.-C.J. Exp. Med. 184:1939-1951(1996)