Alternative Name(s):

70KDA ribosomal protein S6 kinase 2 ;P70S6K2 ;p70-S6K 2S6 kinase-related kinase ;SRKSerine/threonine-protein kinase 14Bp70 ribosomal S6 kinase beta ;S6K-beta ;p70 S6 kinase beta ;p70 S6K-beta ;p70 S6KB ;p70-beta

Species: (Organism)

Homo sapiens (Human)

Gene Names:

RPS6KB2

Tag info:

N-terminal GST-tagged

Target Protein AA Sequence:

MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKL

Expression Region:

1-210aa

Subcellular Location:

Cytoplasm, Nucleus

Tissue Specificity:

Protein Length:

Partial

Pathway:

ErbBsignalingpathway

Mol. Weight:

50.2 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Signal Transduction

Function:

Phosphorylates specifically ribosomal protein S6.

Involvement in disease:

Relevance:

Phosphorylates specifically ribosomal protein S6.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily

Reference:

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.Gout I., Minami T., Hara K., Tsujishita Y., Filonenko V., Waterfield M.D., Yonezawa K.J. Biol. Chem. 273:30061-30064(1998)