Alternative Name(s):

Ceroid-lipofuscinosis neuronal protein 7

Species: (Organism)

Homo sapiens (Human)

Gene Names:

MFSD8

Tag info:

N-terminal 6xHis-GST-tagged

Target Protein AA Sequence:

MAGLRNESEQEPLLGDTPGSREWDILETEEHYKSRWRSIR

Expression Region:

1-40aa

Subcellular Location:

Lysosome membrane, Multi-pass membrane protein

Tissue Specificity:

Expressed at very low levels in all tissues tested.

Protein Length:

Partial

Pathway:

Mol. Weight:

34.8 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

May be a carrier that transport small solutes by using chemiosmotic ion gradients.

Involvement in disease:

Ceroid lipofuscinosis, neuronal, 7 (CLN7); Macular dystrophy with central cone involvement (CCMD)

Relevance:

May be a carrier that transport small solutes by using chemiosmotic ion gradients

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Major facilitator superfamily

Reference:

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005)