Alternative Name(s):

SL3-3 integration site 1 protein Kiaa0991, Sint1

Species: (Organism)

Mus musculus (Mouse)

Gene Names:

Septin9

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

MKKSYSGVTRTSSGRLRRLADPTGPALKRSFEVEEIEPPNSTPPRRVQTPLLRATVASSSQKFQDLGVKNSEPAARLVDSLSQRSPKPSLRRVELAGAKAPEPMSRRTEISIDISSKQVESTASAAGPSRFGLKRAEVLGHKTPEPVPRRTEITIVKPQESVLRRVETPASKIPEGSAVPATDAAPKRVEIQVPKPAEAPNCPLPSQTLENSEAPMSQLQSRLEPRPSVAEVPYRNQEDSEVTPSCVGDMADNPRDAMLKQAPASRNEKAPMEFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVYFKQRITADLLSNGIDVYPQKEFDEDAEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSNIHFEAYRVKRLNEGNSAMANGIEKEPEAQEM

Expression Region:

1-583aa

Subcellular Location:

Cytoplasm, cytoskeleton

Tissue Specificity:

Expressed in all tissues examined except muscle. Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain.

Protein Length:

Full Length

Pathway:

Mol. Weight:

69.6 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Involvement in disease:

Putative proto-oncogene involved in T-cell lymphomagenesis. May play a role in leukemogenesis.

Relevance:

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family

Reference:

"Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family." Soerensen A.B., Lund A.H., Ethelberg S., Copeland N.G., Jenkins N.A., Pedersen F.S. J. Virol. 74:2161-2168(2000)