Alternative Name(s):

C-type lectin-like molecule 1(CLL-1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) ( Micl)

Species: (Organism)

Mus musculus (Mouse)

Gene Names:

Clec12a

Tag info:

N-terminal 10xHis-tagged and C-terminal Myc-tagged

Target Protein AA Sequence:

YTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

Expression Region:

65-267aa

Subcellular Location:

Cell membrane, Single-pass type II membrane protein

Tissue Specificity:

Protein Length:

Partial

Pathway:

Mol. Weight:

30.8 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Involvement in disease:

Relevance:

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

"Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death." Neumann K., Castineiras-Vilarino M., Hockendorf U., Hannesschlager N., Lemeer S., Kupka D., Meyermann S., Lech M., Anders H.J., Kuster B., Busch D.H., Gewies A., Naumann R., Gross O., Ruland J. Immunity 40:389-399(2014)