Alternative Name(s):

Allergen Der p I Major mite fecal allergen Der p 1 Allergen: Der p 1

Species: (Organism)

Dermatophagoides pteronyssinus (European house dust mite)

Gene Names:

DERP1

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

TNACSINGNAPAEIDLRQMRTVTPIRMQGGCGSCWAFSGVAATESAYLAYRNQSLDLAEQELVDCASQHGCHGDTIPRGIEYIQHNGVVQESYYRYVAREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVIIGIKDLDAFRHYDGRTIIQRDNGYQPNYHAVNIVGYSNAQGVDYWIVRNSWDTNWGDNGYGYFAANIDLMMIEEYPYVVIL

Expression Region:

99-320aa

Subcellular Location:

Secreted

Tissue Specificity:

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

38.0 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Thiol protease, with a preference for substrates with a large hydrophobic side chain in the P2 position, or with basic residues.

Involvement in disease:

Relevance:

Thiol protease, with a preference for substrates with a large hydrophobic side chain in the P2 position, or with basic residues.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Peptidase C1 family

Reference:

"Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli."Thomas W.R., Stewart G.A., Simpson R.J., Chua K.Y., Plozza T.M., Dilworth R.J., Nisbet A., Turner K.J.Int. Arch. Allergy Appl. Immunol. 85:127-129(1988)