Alternative Name(s):

Fibrinogen-clotting enzyme Snake venom serine protease

Species: (Organism)

Bitis gabonica (Gaboon adder) (Gaboon viper)

Gene Names:

N/A

Tag info:

Tag-Free

Target Protein AA Sequence:

VVGGAECKIDGHRCLALLY

Expression Region:

1-19aa

Subcellular Location:

Secreted

Tissue Specificity:

Expressed by the venom gland.

Protein Length:

Partial

Pathway:

Mol. Weight:

2 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Thrombin-like snake venom serine protease. Releases both fibrinopeptides A and B from fibrinogen (FGA and FGB) to form fibrin clots. Also activates factor XIII (F13A). The activity of the enzyme is stabilized by calcium ion.

Involvement in disease:

Relevance:

Thrombin-like snake venom serine protease. Releases both fibrinopeptides A and B from fibrinogen (FGA and FGB) to form fibrin clots. Also activates factor XIII (F13A). The activity of the enzyme is stabilized by calcium ion.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Peptidase S1 family, Snake venom subfamily

Reference:

"Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties, and coagulant actions." Pirkle H., Theodor I., Miyada D., Simmons G. J. Biol. Chem. 261:8830-8835(1986)