Alternative Name(s):

ATTRPrealbumin;TBPA

Species: (Organism)

Homo sapiens (Human)

Gene Names:

TTR

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Expression Region:

21-147aa

Subcellular Location:

Secreted, Cytoplasm

Tissue Specificity:

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Protein Length:

Full Length of Mature Protein

Pathway:

Th17celldifferentiation

Mol. Weight:

17.8 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Transport

Function:

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Involvement in disease:

Amyloidosis, transthyretin-related (AMYL-TTR); Hyperthyroxinemia, dystransthyretinemic (DTTRH); Carpal tunnel syndrome 1 (CTS1)

Relevance:

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Transthyretin family

Reference:

Cloning and sequence analysis of cDNA for human prealbumin.Mita S., Maeda S., Shimada K., Araki S.Biochem. Biophys. Res. Commun. 124:558-564(1984)