Alternative Name(s):

21KDA TBP-like protein;Second TBP of unique DNA protein ;STUDTATA box-binding protein-related factor 2 ;TBP-related factor 2TBP-like factorTBP-related protein

Species: (Organism)

Homo sapiens (Human)

Gene Names:

TBPL1

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEI

Expression Region:

1-185aa

Subcellular Location:

Cytoplasm, Nucleus

Tissue Specificity:

Ubiquitously expressed, with highest levels in the testis and ovary.

Protein Length:

Partial

Pathway:

Mol. Weight:

36.8 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Epigenetics and Nuclear Signaling

Function:

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

Involvement in disease:

Relevance:

Part of a specialized transcription syst that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter elent at these genes. Ses to also mediate the transcription of NF1. Does not bind the TATA box.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

TBP family

Reference:

TRF2, but not TBP, mediates the transcription of ribosomal protein genes.Wang Y.L., Duttke S.H., Chen K., Johnston J., Kassavetis G.A., Zeitlinger J., Kadonaga J.T.Genes Dev. 28:1550-1555(2014)