Alternative Name(s):

Leupin Peptidase inhibitor 11 Short name: PI-11 Squamous cell carcinoma antigen 2 Short name: SCCA-2

Species: (Organism)

Homo sapiens (Human)

Gene Names:

SERPINB4

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP

Expression Region:

1-390aa

Subcellular Location:

Cytoplasm

Tissue Specificity:

Squamous cells.

Protein Length:

Full Length

Pathway:

Mol. Weight:

60.9 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Cancer

Function:

May act as a protease inhibitor to modulate the host immune response against tumor cells.

Involvement in disease:

Relevance:

May act as a protease inhibitor to modulate the host immune response against tumor cells.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Serpin family, Ov-serpin subfamily

Reference:

"Identification of a novel human serpin gene; cloning sequencing and expression of leupin."Barnes R.C., Worrall D.M.FEBS Lett. 373:61-65(1995)