Alternative Name(s):

Amyloid fibril protein AA

Species: (Organism)

Canis lupus familiaris (Dog) (Canis familiaris)

Gene Names:

SAA1

Tag info:

N-terminal 6xHis-GST-tagged

Target Protein AA Sequence:

QWYSFVSEAAQGAWDMWRAYSDMREANYKNSDKYFHARGNYDAAQRGPGGAWAAKVISDARENSQRITDLLRFGDSGHGAEDSKADQAANEWGRSGKDPNHFRPAGLPDKY

Expression Region:

19-129aa

Subcellular Location:

Secreted

Tissue Specificity:

Expressed by the liver; secreted in plasma.

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

42.5 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Major acute phase reactant. Apolipoprotein of the HDL complex.

Involvement in disease:

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

Relevance:

Major acute phase reactant. Apolipoprotein of the HDL complex.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

SAA family

Reference:

Dog serum amyloid A protein. Identification of multiple isoforms defined by cDNA and protein analyses.Sellar G.C., Debeer M.C., Lelias J.M., Snyder P.W., Glickman L.T., Felsburg P.J., Whitehead A.S.J. Biol. Chem. 266:3505-3510(1991)