Alternative Name(s):

Rhomboid-like protein 2

Species: (Organism)

Homo sapiens (Human)

Gene Names:

RHBDL2

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

MNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEAWRFISYMLVHAG

Expression Region:

12-132aa

Subcellular Location:

Rhomboid-related protein 2, C-terminal fragment: Cell membrane, Multi-pass membrane protein

Tissue Specificity:

Protein Length:

Partial

Pathway:

Mol. Weight:

18.2 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate

Involvement in disease:

Relevance:

Involved in regulated intrambrane proteolysis and the subsequent release of functional polypeptides from their mbrane anchors. Known substrate: EFNB3.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Peptidase S54 family

Reference:

The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity.Lei X., Li Y.M.J. Mol. Biol. 394:815-825(2009)