Alternative Name(s):

40KDA neuronal protein Onconeuronal antigen Ma2 Paraneoplastic neuronal antigen MM2

Species: (Organism)

Homo sapiens (Human)

Gene Names:

PNMA2

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHE

Expression Region:

2-361aa

Subcellular Location:

Nucleus, nucleolus

Tissue Specificity:

Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.

Protein Length:

Partial

Pathway:

Mol. Weight:

57.1 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Tags & Cell Markers

Function:

Involvement in disease:

Relevance:

Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

PNMA family

Reference:

"A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer." Voltz R., Gultekin S.H., Rosenfeld M.R., Gerstner E., Eichen J., Posner J.B., Dalmau J. N. Engl. J. Med. 340:1788-1795(1999)