Alternative Name(s):

Neurotrophin-5 ;NT-5Neutrophic factor 4

Species: (Organism)

Homo sapiens (Human)

Gene Names:

NTF4

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

VSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA

Expression Region:

82-210aa

Subcellular Location:

Secreted

Tissue Specificity:

Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Protein Length:

Partial

Pathway:

MAPKsignalingpathway

Mol. Weight:

17.9 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Neuroscience

Function:

Target-derived survival factor for peripheral sensory sympathetic neurons.

Involvement in disease:

Glaucoma 1, open angle, O (GLC1O)

Relevance:

Target-derived survival factor for peripheral sensory sympathetic neurons.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

NGF-beta family

Reference:

Neurotrophin-5 a novel neurotrophic factor that activates trk and trkB.Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A.Neuron 7:857-866(1991)