Alternative Name(s):

NCALD; Neurocalcin-delta

Species: (Organism)

Homo sapiens (Human)

Gene Names:

NCALD

Tag info:

N-terminal GST-tagged

Target Protein AA Sequence:

GKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNRDGKLSLEEFIRGAKSDPSIVRLLQCDPSSAGQF

Expression Region:

1-193aa

Subcellular Location:

Tissue Specificity:

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Protein Length:

Full Length

Pathway:

Mol. Weight:

49.1 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Neuroscience

Function:

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Involvement in disease:

Relevance:

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Recoverin family

Reference:

"Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy." Kamiyama M., Kobayashi M., Araki S., Iida A., Tsunoda T., Kawai K., Imanishi M., Nomura M., Babazono T., Iwamoto Y., Kashiwagi A., Kaku K., Kawamori R., Ng D.P., Hansen T., Gaede P., Pedersen O., Nakamura Y., Maeda S. Hum. Genet. 122:397-407(2007)