Alternative Name(s):

Short name: IL-7 receptor subunit alpha Short name: IL-7R subunit alpha Short name: IL-7R-alpha Short name: IL-7RA

Species: (Organism)

Mus musculus (Mouse)

Gene Names:

Il7r

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

ESGNAQDGDLEDADADDHSFWCHSQLEVDGSQHLLTCAFNDSDINTANLEFQICGALLRVKCLTLNKLQDIYFIKTSEFLLIGSSNICVKLGQKNLTCKNMAINTIVKAEAPSDLKVVYRKEANDFLVTFNAPHLKKKYLKKVKHDVAYRPARGESNWTHVSLFHTRTTIPQRKLRPKAMYEIKVRSIPHNDYFKGFWSEWSPSSTFETPEPKNQGGWD

Expression Region:

21-239aa

Subcellular Location:

Membrane, Single-pass type I membrane protein

Tissue Specificity:

Spleen, thymus and fetal liver.

Protein Length:

Extracellular Domain

Pathway:

Mol. Weight:

41 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Immunology

Function:

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Involvement in disease:

Relevance:

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Type I cytokine receptor family, Type 4 subfamily

Reference:

"Structural basis of the proinflammatory signaling complex mediated by TSLP."Verstraete K., van Schie L., Vyncke L., Bloch Y., Tavernier J., Pauwels E., Peelman F., Savvides S.N.Nat. Struct. Mol. Biol. 21:375-382(2014)