Alternative Name(s):

Progonadoliberin II

Species: (Organism)

Homo sapiens (Human)

Gene Names:

GNRH2

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

QHWSHGWYPGGKRALSSAQDPQNALRPPGRALDTAAGSPVQTAHGLPSDALAPLDDSMPWEGRTTAQWSLHRKRHLARTLLTAAREPRPAPPSSNKV

Expression Region:

24-120aa

Subcellular Location:

Secreted

Tissue Specificity:

Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.

Protein Length:

Full Length of Mature Protein

Pathway:

Mol. Weight:

26.5 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Signal Transduction

Function:

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Involvement in disease:

Relevance:

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

GnRH family

Reference:

Second gene for gonadotropin-releasing hormone in humans.White R.B., Eisen J.A., Kasten T.L., Fernald R.D.Proc. Natl. Acad. Sci. U.S.A. 95:305-309(1998)