Alternative Name(s):

Short name: GLP-1 receptor Short name: GLP-1-R Short name: GLP-1R

Species: (Organism)

Mus musculus (Mouse)

Gene Names:

Glp1r

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

GPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLY

Expression Region:

22-145aa

Subcellular Location:

Cell membrane, Multi-pass membrane protein

Tissue Specificity:

Detected in pancreatic islets (at protein level). Detected in pancreatic islets and lungs.

Protein Length:

Partial

Pathway:

Mol. Weight:

30.4 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Neuroscience

Function:

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1)

Involvement in disease:

Relevance:

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

G-protein coupled receptor 2 family

Reference:

"Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene."Flamez D., van Breusegem A., Scrocchi L.A., Quartier E., Pipeleers D., Drucker D.J., Schuit F.Diabetes 47:646-652(1998)