Alternative Name(s):

DPPXDipeptidyl aminopeptidase-related proteinDipeptidyl peptidase 6Dipeptidyl peptidase IV-like proteinDipeptidyl peptidase VI ;DPP VI

Species: (Organism)

Rattus norvegicus (Rat)

Gene Names:

DPP6

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

LTPAEDTSLSQKKKVTVEDLFSEDFKIHDPEAKWISDKEFIYRERKGSVILRNVETNNSTVLIEGKKIESLRAIRYEISPDKEYALFSYNVEPVYQHSHTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLMELPTYTGSVYPTVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTEILTYDEKRNKLYFLSTEDLPRRRHLYSANTVDDFNRQCLSCDLVENCTYVSASFSHNMDFFLLKCEGPGVPTVTVHNTTDKRRMFDLEANEQVQKAIYDRQMPKIEYRKIEVEDYSLPMQILKPATFTDTAHYPLLLVVDGTPGSQSVSERFEVTWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGFLEEKDQMEAVRTMLKEQYIDKTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKLAHRVSALEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIYPDESHYFHSVALKQHLYRSIIGFFVECFRIQDKLPTATAKEDEEED

Expression Region:

111-859aa

Subcellular Location:

Cell membrane, Single-pass type II membrane protein

Tissue Specificity:

Detected in brain cortex, hippocampus, thalamus and cerebellum granule cells (at protein level) (PubMed:16123112). Isoform DPPX-S is expressed in brain and some peripheral tissues including kidney, ovary, and testis; in contrast isoform DPPX-L is expressed almost exclusively in brain.

Protein Length:

Extracellular Domain

Pathway:

Mol. Weight:

89.6 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Promotes cell surface expression of the potassium channel KCND2

Involvement in disease:

Relevance:

Promotes cell surface expression of the potassium channel KCND2 . Modulates the activity and gating characteristics of the potassium channel KCND2 . Has no dipeptidyl aminopeptidase activity .

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Peptidase S9B family

Reference:

The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels.Kaulin Y.A., De Santiago-Castillo J.A., Rocha C.A., Nadal M.S., Rudy B., Covarrubias M.J. Neurosci. 29:3242-3251(2009)