Alternative Name(s):

Cathepsin OCathepsin O2;Cathepsin X

Species: (Organism)

Homo sapiens (Human)

Gene Names:

CTSK

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM

Expression Region:

115-329aa

Subcellular Location:

Lysosome

Tissue Specificity:

Predominantly expressed in osteoclasts (bones).

Protein Length:

Full Length of Mature Protein

Pathway:

Apoptosis

Mol. Weight:

27.5 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Signal Transduction

Function:

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Involvement in disease:

Pycnodysostosis (PKND)

Relevance:

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone rodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in Extracellular domain matrix degradation.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Peptidase C1 family

Reference:

Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population.Haagerup A., Hertz J.M., Christensen M.F., Binderup H., Kruse T.A.Eur. J. Hum. Genet. 8:431-436(2000)