Alternative Name(s):

CD_antigen: CD46

Species: (Organism)

Cavia porcellus (Guinea pig)

Gene Names:

CD46

Tag info:

N-terminal 6xHis-tagged

Target Protein AA Sequence:

CVLPPPFEAMEPINPKPYYEIGEKVEYRCKKGYLRQPFYLMVATCEKNHSWVPITDDGCIKKQCTYLNPPPKGRVEYINGTRTWGDIVHFSCVEGFYVSGIAALSCELRGDNVDWNGRVPTCEKVLCSPPPKIQNGKYTFSDVQVFEYFEAVTYSCDAVQGPDKLSLVGNEVLYCAGHQKWSSAAPECKVVKCPLPVVKNGKQISGLGQTFFYQATVTFQCLPGFYFNGSSTVVCGSDNTWKPSIPECLKGPKPTHPTKPPVYNYPGYPNPREGIFDQELN

Expression Region:

36-316aa

Subcellular Location:

Membrane, Single-pass type I membrane protein

Tissue Specificity:

Preferentially expressed in testis.

Protein Length:

Extracellular Domain

Pathway:

Mol. Weight:

35.4 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.

Involvement in disease:

Relevance:

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

"Molecular cloning of guinea pig membrane cofactor protein: preferential expression in testis."Hosokawa M., Nonaka M., Okada N., Nonaka M., Okada H.J. Immunol. 157:4946-4952(1996)