Alternative Name(s):

Calcium-activated neutral proteinase small subunit ;CANP small subunit;Calcium-dependent protease small subunit ;CDPSCalcium-dependent protease small subunit 1;Calpain regulatory subunit

Species: (Organism)

Homo sapiens (Human)

Gene Names:

CAPNS1

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS

Expression Region:

1-268aa

Subcellular Location:

Cytoplasm, Cell membrane

Tissue Specificity:

Protein Length:

Full Length

Pathway:

Mol. Weight:

44.3 kDa

Purity:

Greater than 90% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Signal Transduction

Function:

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Involvement in disease:

Relevance:

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal rodeling and signal transduction.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease.Ohno S., Emori Y., Suzuki K.Nucleic Acids Res. 14:5559-5559(1986)