Alternative Name(s):

gp84 gp94

Species: (Organism)

Borna disease virus (strain V) (BDV)

Gene Names:

G

Tag info:

N-terminal 6xHis-SUMO-tagged

Target Protein AA Sequence:

FDLQGLSCNTDSTPGLIDLEIRRLCHTPTENVISCEVSYLNHTTISLPAVHTSCLKYHCKTYWGFFGSYSADRIINRYTGTVKGCLNNSAPEDPFECNWFYCCSAITTEICRCSITNVTVAVQTFPPFMYCSFADCSTVSQQELESGKAMLSDGSTLTYTPYILQSEVVNKTLNGTILCNSSSKIVSFDEFRRSYSLTNGSYQSSSINVTCANYTSSCRPRLKRRRRDTQQIEYLVHKLRPTLKDAWEDCEILQSLLLGVFGTGIASASQFLRSWLNHPDIIGYIVNGVGVVWQCHRVNVTFMAWNESTYYPPVDYNGRKYFLNDEGRLQTNTPEARPGLKRVMWFGRYFLGTVGSGVKPRRIRYNKTSHDYHLEEFEASLNMTPQTSIASGHETDPINHAYGTQADLLPYTRSSNITSTDTGSGWVHIGLPSFAFLNPLGWLRD

Expression Region:

23-467aa

Subcellular Location:

Envelope glycoprotein p57: Host endoplasmic reticulum membrane, Single-pass type I membrane protein, Note=Accumulates in the endoplasmic reticulum when unprocessed, whereas cleaved products reaches cell surface, SUBCELLULAR LOCATION: Envelope glycoprotein p27: Virion, Host cell membrane, Peripheral membrane protein, Note=Appear to be associated with infectious virions, SUBCELLULAR LOCATION: Envelope glycoprotein p29: Virion, Host cell membrane, Single-pass type I membrane protein

Tissue Specificity:

Protein Length:

Extracellular Domain

Pathway:

Mol. Weight:

66.2 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Unprocessed envelope protein p57 is thought to be involved in attachment of the virus to its cell surface receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).

Involvement in disease:

Relevance:

Unprocessed envelope protein p57 is thought to be involved in attachment of the virus to its cell surface receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Envelope protein p27 and p29 presumably linked by disulfide bond are the viral type II fusion protein, involved in pH-dependent fusion within early endosomes after internalization of the virion by endocytosis.

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Reference:

"Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus." Pleschka S., Staeheli P., Kolodziejek J., Richt J.A., Nowotny N., Schwemmle M. J. Gen. Virol. 82:2681-2690(2001)