Alternative Name(s):

NADH dehydrogenase subunit 1 MTND1, NADH1, ND1

Species: (Organism)

Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis)

Gene Names:

MT-ND1

Tag info:

N-terminal 10xHis-SUMO-tagged

Target Protein AA Sequence:

MLVMLTSTLILVLMVLLAVAFLTMVERKTLGYMQLRKGPNVVGFMGLLQPIADGVKLFLKEPVWPTAASPALFIAAPIMALTLALSLWMFIPMPQSISTINLTLLVILAISSLSVYASLGSGWASNSKYALIGALRAVAQTISYEVSLGLILLCLIILTGGFSLQAFIYTQEHTWFLLSSWPLAAMWFVSTLAETNRTPFDLTEGESELVSGFNVEYAGGPFALFFLAEYSNILFMNTLTAIMFLGPLGPNNLNILPIINVMMKATPLIILFLWIRASYPRFRYDQLMHLMWKNFLPLNLALFTLQLSLAVSLGGAGVPQM

Expression Region:

1-321aa

Subcellular Location:

Mitochondrion inner membrane, Multi-pass membrane protein

Tissue Specificity:

Protein Length:

Full Length

Pathway:

Mol. Weight:

53.8 kDa

Purity:

Greater than 85% as determined by SDS-PAGE.

Form:

Liquid or Lyophilized powder

Buffer:

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Research Areas:

Others

Function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Involvement in disease:

Relevance:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Protein Families:

Complex I subunit 1 family

Reference:

"The main features of the craniate mitochondrial DNA between the ND1 and the COI genes were established in the common ancestor with the lancelet." Delarbre C., Barriel V., Tillier S., Janvier P., Gachelin G. Mol. Biol. Evol. 14:807-813(1997)