Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Classification:

Primary antibody

Alternative names:

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Species reactivity:

Human

Host:

Mouse

Isotype:

IgG

Immunogen:

Purified recombinant fragment of human Rb expressed in E. Coli.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for one year

More info:

Email: info@sobekbio.com

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