Background:

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.

Classification:

Primary antibody

Alternative names:

PDK1; PDHK1; Pyruvate dehydrogenase (lipoamide) kinase isozyme 1; mitochondrial; Pyruvate dehydrogenase kinase isoform 1

Species reactivity:

Human,Rat,Monkey

Host:

Mouse

Isotype:

IgG

Immunogen:

Purified recombinant fragment of human PDK1 expressed in E. Coli.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

WB, IHC-p, IF, ICC, FCM, ELISA

Storage:

-20°C for one year

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