Background:

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Classification:

Primary antibody

Alternative names:

MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1

Species reactivity:

Human,Monkey

Host:

Mouse

Isotype:

IgG

Immunogen:

Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for one year

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