Background:

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Classification:

Primary antibody

Alternative names:

ATIC; PURH; OK/SW-cl.86; Bifunctional purine biosynthesis protein PURH

Species reactivity:

Human,Rb

Host:

Mouse

Isotype:

IgG

Immunogen:

Purified recombinant human IMP cyclohydrolase protein fragments expressed in E.coli.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

WB

Storage:

-20°C for one year

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