Background:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Classification:

Primary antibody

Alternative names:

CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38

Species reactivity:

Human,Mouse,Dog,Rb

Host:

Mouse

Isotype:

IgG

Immunogen:

Purified recombinant human Crk II protein fragments expressed in E.coli.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

WB

Storage:

-20°C for one year

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