Background:

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.

Classification:

Primary antibody

Alternative names:

ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41

Species reactivity:

Human

Host:

Mouse

Isotype:

IgG

Immunogen:

Synthetic Peptide of CD41

Concentration:

1 mg/ml

Molecular weight:

113391

Applications:

IHC-p, IF

Storage:

-20°C for one year

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