Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Classification:

Primary antibody

Alternative names:

Signal transducer and activator of transcription 4; STAT4; Signal transducer and activator of transcription 4

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phospho-peptide around the phosphorylation site of human Stat4 (phospho Tyr693)

Concentration:

1 mg/ml

Molecular weight:

85941

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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