Background:

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Contains 1 cyclic nucleotide-binding domain.,Contains 1 N-terminal Ras-GEF domain.,Contains 1 PDZ (DHR) domain.,Contains 1 Ras-associating domain.,Contains 1 Ras-GEF domain.,subcellular location:Upon binding to M-Ras, it translocates to the plasma membrane.,subunit:Interacts with the second PDZ domain of human PTP1e.,tissue specificity:Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.,

Classification:

Primary antibody

Alternative names:

Rap guanine nucleotide exchange factor 6 ;PDZ domain-containing guanine nucleotide exchange factor 2;PDZ-GEF2;RA-GEF-2

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human protein . at AA range: 460-540

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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