Background:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Classification:

Primary antibody

Alternative names:

Presenilin-2; PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Presenilin 2 around the phosphorylation site of Ser330. AA range:296-345

Concentration:

1 mg/ml

Molecular weight:

50140

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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