Background:

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,Belongs to the protein kinase superfamily.,Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,Contains 1 PH domain.,Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,

Classification:

Primary antibody

Alternative names:

3-phosphoinositide-dependent protein kinase 1; PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PDK1 around the phosphorylation site of Tyr9. AA range:1-50

Concentration:

1 mg/ml

Molecular weight:

63152

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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