Background:

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.

Classification:

Primary antibody

Alternative names:

Serine/threonine-protein kinase PAK 6/7; PAK7; KIAA1264; PAK5; Serine/threonine-protein kinase PAK 7; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; PAK6; PAK5; Serine/threonine-protein kinase PAK 6; PAK-5; p21-activated kinase 6; PAK-6

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PAK5/6 around the phosphorylation site of Ser602/Ser560. AA range:566-615

Concentration:

1 mg/ml

Molecular weight:

74869

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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