Background:

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Classification:

Primary antibody

Alternative names:

Leptin; LEP; OB; OBS; Leptin; Obese protein; Obesity factor

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Ob. AA range:36-85

Concentration:

1 mg/ml

Molecular weight:

18641

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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