Background:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced trans

Classification:

Primary antibody

Alternative names:

ATP-sensitive inward rectifier potassium channel 11; KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K;+ channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Kir6.2 around the phosphorylation site of Thr224. AA range:190-239

Concentration:

1 mg/ml

Molecular weight:

43562

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

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