Background:

cofactor:Binds 1 Fe(2+) ion per subunit.,Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.,Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.,miscellaneous:Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.,Belongs to the JHDM2 histone demethylase family.,Contains 1 JmjC domain.,tissue specificity:Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.,

Classification:

Primary antibody

Alternative names:

Lysine-specific demethylase 3B ;EC 1.14.11.-;JmjC domain-containing histone demethylation protein 2B;Jumonji domain-containing protein 1B;Nuclear protein 5qNCA

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human protein . at AA range: 230-310

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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