Background:

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

Integrin beta-4; ITGB4; Integrin beta-4; GP150; CD antigen CD104

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human ITGB4 around the phosphorylation site of Tyr1510. AA range:1481-1530

Concentration:

1 mg/ml

Molecular weight:

202151

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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