Background:

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Insulin receptor; INSR; Insulin receptor; IR; CD antigen CD220

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1361. AA range:1331-1380

Concentration:

1 mg/ml

Molecular weight:

156307

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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